Transcriptional Regulation of the Pendrin Gene

Transcriptional regulation of the pendrin gene.

Pendrin (SLC26A4), a Cl(-)/anion exchanger encoded by the gene PDS, is highly expressed in the kidney, thyroid and inner ear epithelia and is essential for bicarbonate secretion/chloride reabsorption, iodide accumulation and endolymph ion balance, respectively. The molecular mechanisms controlling pendrin activity in renal, thyroid and inner ear epithelia have been the subject of recent studies...

The transcriptional regulation of the preproenkephalin gene.

Transcriptional regulation of the human TLR9 gene.

To clarify the molecular basis of human TLR9 (hTLR9) gene expression, the activity of the hTLR9 gene promoter was characterized using the human myeloma cell line RPMI 8226. Reporter gene analysis and EMSA demonstrated that hTLR9 gene transcription was regulated via four cis-acting elements, cAMP response element, 5'-PU box, 3'-PU box, and a C/EBP site, that interacted with the CREB1, Ets2, Elf1...

Transcriptional regulation of the human CYP2A6 gene.

Nicotine C-oxidation is primarily catalyzed by CYP2A6 in humans. This enzymatic activity exhibits a large interindividual variability, which to a great extent is caused by genetic polymorphisms in the CYP2A6 gene. There are large interindividual differences in CYP2A6 mRNA and protein levels, but little is known about the transcriptional regulation of CYP2A6, which can, e.g., explain such differ...

Transcriptional regulation of the apolipoprotein AI gene.

Since the original description of the gene encoding apolipoprotein AI (apoAI) considerable progress has been made in identifying the regulatory regions and corresponding transcription factors that regulate its transcription in liver and intestinal cells. Nuclear receptors (in particular HNF-4) have emerged as the dominant (although by no means the exclusive) transcriptional activators that driv...